INTEGRA develops laboratory equipment for the automation of process steps in biological and chemical research laboratories. The core products of INTEGRA are electronic multi-channel pipettes and pipetting robots, such as ASSIST PLUS.
The aim was to increase the level of automation of INTEGRA pipetting robots with regard to Magnetic Bead Separation for DNA Purification/Extraction. Two modules were developed in parallel, one of which offers an additional heating function.
INTEGRA defined the following product vision guidelines:
- High value and quality
- Compactness
- High compatibility with labware and control interfaces
The Helbling team's extensive experience in system integration allowed the well-coordinated core team to work closely and trustfully with INTEGRA to develop an optimal solution for the magnetic mechanism, spill protection, and various control options within extremely limited space. In addition, the broad knowledge of Helbling enabled the targeted involvement of experts in various areas.
Key Figures
- The module combines strong magnets and heating elements in a compact device (SBS footprint)
- Optimized purification through automatic bead collection using vertical magnet movements
- Heating function up to 65°C for lysis and elution steps
- Magnet height adjustable for bead collection depending on volume
- Bluetooth communication enables intuitive operation via MAG Control App
- Possibility of full automation in combination with the ASSIST PLUS pipetting robot
Our Contribution
After an internal feasibility study, INTEGRA commissioned Helbling with the overall development of the two modules until series production readiness. The following services were provided by Helbling:
- Deriving the requirements
- Designing and evaluating concepts
- Creating the electronics, mechanics, and firmware in two iterations
- Verifying the solution
- Approval by TÜV
Outcome
The MAG and HEATMAG modules launched in February 2024 enable automatic Magnetic Bead Separation Processes on the INTEGRA pipetting robots. The modules can be operated via the robot, PC, smartphone, or manually.
